Yui Kawamoto

Yui Hiraguri’s research works | Tokyo Medical and Dental University, Tokyo (TMDU) and other places

Publications (14)


… IBD is usually accompanied by imbalance of pro-inflammatory and anti-inflammatory signaling pathways in the intestine. Increasing evidences suggest that nuclear factor-κB (NF-ĸB) plays a vital role in the pathogenesis of IBD, and the degree of activated NF-ĸB is significantly correlated with the severity of inflammation of the intestine and the colon [6][7][8][9] . Various pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α regulated by NF-ĸB were found increased in IBD patients 6,10 . …

… Some studies demonstrate that the number and quality of isolated crypts from inflamed regions of CD and ulcerative colitis patients is too low to regularly form intestinal organoids (Dotti et al., 2017;Yoo and Donowitz, 2019). On the other hand, some studies report that the organoid-forming capacity is similar be-tween inflamed and non-inflamed areas of CD patients and are similar to healthy controls (Dotti et al., 2017;Noben et al., 2017;Suzuki et al., 2018;VanDussen et al., 2015). We believe that, unlike our murine study, these studies have not utilized a standard scoring technique to quantify the degree of inflammation in the affected/inflamed areas of CD patients. …

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